missing translation for 'onlineSavingsMsg'
Learn More
Learn More
P27/KIP1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 26714-1-AP-150UL
This item is not returnable.
View return policy
Description
p27 Kip1 functions as a negative regulator of G1 mouse expression and has been proposed to function as a possible mediator of TGFb induced G1 arrest. p27 Kip1 is an important regulator of cell cycle progression, a potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. p27 Kip1 forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. p27 Kip1 acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichiometry. p27 Kip1 has a molecular weight of approximately 27 kDa and the degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.Specifications
| P27/KIP1 | |
| Polyclonal | |
| Unconjugated | |
| CDKN1B | |
| CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27, P27; KIP1, P27KIP1 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 1027, 12576 | |
| -20°C | |
| Liquid |
| Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot | |
| 0.77 mg/mL | |
| PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
| P46414, P46527 | |
| CDKN1B | |
| P27; KIP1 Fusion Protein Ag25083 | |
| 150 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
Product Content Correction
Your input is important to us. Please complete this form to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?Share a Content Correction