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Vinculin Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 26520-1-AP-150UL

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Product Code. 16854955

  • 4652.90 SEK / 150µL

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Description

Description

Vinculin (VCL) is a cytoskeletal protein associated with cell-cell and cell-extracellular matrix adherens-type junctions. It functions as one of several interacting proteins involved in anchoring F-actin to the membrane. It has been shown that a sequence of molecular interactions might be involved in the transmembrane assembly of adhesion plaques. In the assembly of adhesion plaques, the beta subunit of integrin binds to talin. Talin binds to vinculin that interacts with alpha-actinin and possibly with itself. Since alpha-actinin binds to and cross-links actin filaments, vinculin represents a key element in the transmembrane linkage of the extracellular matrix to the cytoplasmic microfilament system. Mutations in the gene can result in cardiomyopathy dilated 1W or familial hypertrophic 15.
Specifications

Specifications

Vinculin
Polyclonal
Unconjugated
VCL
CMD1W, Metavinculin, MVCL, VCL, Vinculin
Rabbit
Antigen Affinity Chromatography
RUO
22330, 7414
-20°C
Liquid
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
0.4 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P18206, Q64727
VCL
Vinculin Fusion Protein Ag24942
150 μL
Primary
Human, Mouse
Antibody
IgG
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