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THEM4 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 14692-1-AP-20UL
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Description
THEM4, also known as CTMP, binds specifically to the carboxy-terminal regulatory domain of PKB/Akt at the plasma membrane and acts as a negative regulator, reversing the phenotype of v-Akt-transformed cells. Hypermethylation of the THEM4 promoter and transcriptional downregulation of the gene has been reported in multiple glioblastomas, suggesting that epigenetic regulation of THEM4 may play a role in the progression of this cancer. Bioinformatic analysis, confirmed by in vitro testing, indicates that THEM4 is a broad-range, high activity acyl-CoA thioesterase. Recent reports have also indicated that TMEM4 is a mitochondrial protein whose overexpression is associated with an increase in mitochondrial membrane depolarization and caspase-3 and PARP cleavage, suggesting that THEM4 is involved in the apoptotic program.Specifications
| THEM4 | |
| Polyclonal | |
| Unconjugated | |
| THEM4 | |
| CTMP, THEM4 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 117145, 361992, 75778 | |
| -20°C | |
| Liquid |
| Immunofluorescence, Immunoprecipitation, Western Blot, Immunohistochemistry (Paraffin), Immunocytochemistry | |
| 0.63 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| Q3UUI3, Q566R0, Q5T1C6 | |
| Them4 | |
| THEM4 Fusion Protein Ag6244 | |
| 20 μL | |
| Primary | |
| Mouse, Rat, Human | |
| Antibody | |
| IgG |
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