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BACE2 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA519950

Product Code. 12838162

  • 4515.00 SEK / 100µg

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Description

Description

A suggested positive control is human heart tissue lysate. PA5-19950 can be used with blocking peptide PEP-0075.

BACE2 or Beta Secretase 2 is responsible for the proteolytic processing of the amyloid precursor protein (APP). BACE2 cleaves APP between residues 690 and 691. This cleavage leads to the generation and extracellular release of beta-cleaved soluble APP. BACE2 is also know to cleave APP between residues 671 and 672. Accumulation of APP is a signature of Alzheimer disease and frequent complication of adult Down syndrome patients.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

BACE2
Polyclonal
Unconjugated
BACE2
1110059C24Rik; 56 kDa aspartic-like protease; AEPLC; AI850424; ALP56; ARP1; asp 1; ASP1; ASP21; Aspartic-like protease 56 kDa; Aspartyl protease 1; Bace2; BAE2; be; beta secretase 2; Beta-secretase 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2; beta-site amyloid precursor protein cleaving enzyme 2; Beta-site APP cleaving enzyme 2; beta-site APP-cleaving enzyme 2; CDA13; CEAP1; Down region aspartic protease; Down syndrome region aspartic protease; DRAP; memapsin 1; memapsin-1; Membrane-associated aspartic protease 1; theta-secretase; transmembrane aspartic proteinase Asp1; UNQ418/PRO852
Rabbit
Antigen affinity chromatography
RUO
25825, 288227, 56175
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Liquid
Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q6IE75, Q9JL18, Q9Y5Z0
BACE2
A synthetic peptide corresponding to amino acids 44 to 59 of human BACE2.
100 μg
Primary
Human, Mouse, Rat
Antibody
IgG
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